Affiliation between Neu5Gc carbohydrate and serum antibodies in opposition to it supplies the molecular hyperlink to most cancers: French NutriNet-Santé research
Background: Excessive consumption of pink and processed meat is usually related to elevated most cancers danger, notably colorectal most cancers. Antibodies in opposition to the pink meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate most cancers in “human-like” mice. Human anti-Neu5Gc IgG and pink meat are each independently proposed to extend most cancers danger, but how weight-reduction plan impacts these antibodies is essentially unknown.
Strategies: We used world world knowledge to exhibit that colorectal most cancers incidence and mortality are related to elevated nationwide meat consumption. In a well-defined massive cohort, we used glycomics to measure day by day Neu5Gc consumption from pink meat and dairy, and investigated serum in addition to affinity-purified anti-Neu5Gc antibodies.
Primarily based on 24-h dietary data, day by day Neu5Gc consumption was calculated for 19,621 topics aged ≥ 18 years of the NutriNet-Santé research. Serum and affinity-purified anti-Neu5Gc antibodies have been evaluated by ELISA and glycan microarrays in consultant 120 people, every with at the very least eighteen 24-h dietary data (aged 45-60, Q1-This fall; aged > 60, Q1 and This fall; 10 males/girls per quartile).
Outcomes: We discovered that high-Neu5Gc weight-reduction plan, gender, and age have an effect on the specificity, ranges, and repertoires of anti-Neu5Gc IgG immune responses, however not their affinity. Males consumed extra Neu5Gc than girls, principally from pink meat (p = 0.0015), and exhibited greater general serum anti-Neu5Gc IgG ranges by ELISA (3.94 ng/μl versus 2.22 ng/μl, respectively; p = 0.039). Detailed glycan microarray evaluation in opposition to 56 totally different glycans revealed excessive Neu5Gc-specificity with elevated anti-Neu5Gc IgG and altered repertoires, related to greater consumption of Neu5Gc from pink meat and cow dairy.
Affinity purification of serum anti-Neu5Gc antibodies revealed elevated ranges and biased array repertoire patterns, with out a rise in antibody affinity, in people consuming greater Neu5Gc ranges. Moreover, in a high-meat weight-reduction plan, antibody variety patterns on glycan microarrays shifted in the direction of Neu5Gcα3-linked glycans, rising the α3/α6-glycans ratio rating.
Conclusions: We discovered a transparent hyperlink between the degrees and repertoire of serum anti-Neu5Gc IgG and Neu5Gc consumption from pink meat and dairy. These exact rational methodologies allowed to develop a Gcemic index to simplify the evaluation of Neu5Gc in meals that would doubtlessly be tailored for dietary suggestions to cut back most cancers danger.
Molecular Mechanism of HER2 Fast Internalization and Redirected Trafficking Induced by Anti-HER2 BiparatopicAntibody
- Amplification and overexpression of HER2 (human epidermal development issue receptor 2), an ErbB2 receptor tyrosine kinase, have been implicated in human most cancers and metastasis. A bispecific tetravalent anti-HER2 antibody (anti-HER2-Bs), focusing on two non-overlapping epitopes on HER2 in area IV (trastuzumab) and area II (39S), has been reported to induce speedy internalization and environment friendly degradation of HER2 receptors.
- On this research, we investigated the molecular mechanism of this antibody-induced speedy HER2 internalization and intracellular trafficking. Utilizing quantitative fluorescent imaging, we in contrast the internalization kinetics of anti-HER2-Bs and its parental arm antibodies, alone or in mixtures and beneath numerous internalization-promoting circumstances. The outcomes demonstrated that concurrent engagement of each epitopes was crucial for speedy anti-HER2-Bs internalization.
- Mobile uptake of anti-HER2-Bs and parental arm antibodies occurred by way of clathrin-dependent endocytosis; nonetheless, contained in the cells antibodies directed totally different trafficking pathways. Trastuzumab dissociated from HER2 in 2 h, enabling the receptor to recycle, whereas anti-HER2-Bs stayed related to the receptor all through the whole endocytic pathway, selling receptor ubiquitination, trafficking to the lysosomes, and environment friendly degradation.
- In keeping with routing HER2 to degradation, anti-HER2-Bs considerably decreased HER2 shedding and altered its exosomal export. Collectively, these outcomes allow a greater understanding of the mechanism of motion of anti-Her2-Bs and may information the rational design of anti-HER2 therapeutics in addition to different bispecific molecules.
Receptor-binding domain-specific human neutralizing monoclonal antibodies in opposition to SARS-CoV and SARS-CoV-2
The outbreaks of extreme acute respiratory syndrome (SARS) and Coronavirus Illness 2019 (COVID-19) brought on by SARS-CoV and SARS-CoV-2, respectively, have posed extreme threats to world public well being and the economic system. Therapy and prevention of those viral illnesses name for the analysis and growth of human neutralizing monoclonal antibodies (NMAbs).
Scientists have screened neutralizing antibodies utilizing the virus receptor-binding area (RBD) as an antigen, indicating that RBD incorporates a number of conformational neutralizing epitopes, that are the principle structural domains for inducing neutralizing antibodies and T-cell immune responses. This assessment summarizes the construction and performance of RBD and RBD-specific NMAbs in opposition to SARS-CoV and SARS-CoV-2 at the moment beneath growth.
Bacillus Calmette-Guérin-induced perinuclear antineutrophil cytoplasmic antibodies associated vasculitis in bladder cancer
Intravesical instillation of Bacillus Calmette-Guérin (BCG) immunotherapy remains the most effective adjuvant treatment for noninvasive bladder cancer. Systemic BCG-related complications are rare and usually related to infective agent or an immune-mediated reaction. We discussed a case with perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) vasculitis, developing after instillation of BCG for non-invasive bladder cancer. A 68-year-old man presented with nephritic syndrome a few months after BCG instillations which was performed for his non-muscle-invasive bladder cancer adjuvant therapy.
The renal function had declined slowly after the first instillation and urinary sediment reveals the new onset of nephritic proteinuria and hematuria. High titer of p-ANCA was present. His renal biopsy was consistent with acute renal vasculitis. The patient’s creatinine level regressed with immunosuppressive therapy and he was clinically followed up without hemodialysis. Here, we presented a patient that diagnosed as p-ANCA related vasculitis occurred after BCG instillation.
Attenuation of antibody titer of measles and rubella virus among university students of department of healthcare providers during 2015-2018 in Japan
Background: In Japan, measles elimination was confirmed in March 2015. Nevertheless, some outbreaks with cases imported from abroad were reported even after certification. A large rubella outbreak has been occurring since 2017. This study examines measurement of the speed of attenuation of antibody titer for a measles virus comparison with rubella virus.
Method: Student subjects born from April 2, 1996 through April 1, 2000 were selected at Ibaraki Prefectural University of Health Sciences for this study: 177 for measles and 114 for rubella. They had available dates of additional immunization and antibodies in the following period and were judged as requiring additional immunization. We used enzyme immunoassay for IgG antibody testing. We regressed post-antibody titers of measles or rubella on pre-antibody titers and functions of duration between inoculation to post-evaluation. Functions of duration were selected according to the adjusted coefficient of determination.
Results: For measles, only a linear term of duration or log of duration was found to be significant without the quadratic terms. For rubella, we selected a five-order linear model which indicated that titer after vaccination would converge to 19.2.
Discussion: Results demonstrate that measles antibody decreased monotonically. If the pre-antibody titer was 15, vaccination raised titer quickly to 26; then it attenuated by 0.014 per day. Antibody titer is expected to be less than 16, which is the protection level of titer, after 704 days. For rubella, however, when pre-vaccination titer was evaluated at its average, the lower limit was 19.2. Therefore, protection can be maintained for a long time. This difference might reflect some circumstances of outbreaks of the respective diseases.
Conclusion: This report describes the speed of attenuation and the epidemiological situation. The speed of attenuation can be expected to rise. Therefore, additional vaccination every several years might be necessary to maintain a protection level if a disease is almost eliminated.
) Human Galectin-1 (LGALS1) | |||
| 1-CSB-EP012882HUb1 | Cusabio |
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Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli | |||
ELISA Kit) Human Galectin-3(Galectin-3)ELISA Kit | |||
| YLA0216HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Galectin-3(Galectin-3)ELISA Kit | |||
| YLA0216HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
 Anti Human Galectin-3 Polyclonal Antibody | |||
| KH040 | Sceti | each | EUR 778.8 |
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. | |||
 Recombinant Human Galectin-1 | |||
| 7-00427 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Galectin-1 | |||
| 7-00428 | CHI Scientific | 50µg | Ask for price |
Recombinant Human Galectin-1 | |||
| 7-00429 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Galectin-1 | |||
| HEOPP-0710 | Cyagen | 10ug | Ask for price |
 Human Galectin 1 Protein | |||
| 20-abx066725 | Abbexa |
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 Galectin-1, human recombinant | |||
| 4648-10 | Biovision | each | EUR 170.4 |
Galectin-1, human recombinant | |||
| 4648-1000 | Biovision | each | EUR 1977.6 |
Galectin-1, human recombinant | |||
| 4648-50 | Biovision | each | EUR 314.4 |
 Human Galectin 1 ELISA kit | |||
| E01G0038-192T | BlueGene | 192 tests | EUR 1524 |
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
Human Galectin 1 ELISA kit | |||
| E01G0038-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
Human Galectin 1 ELISA kit | |||
| E01G0038-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
 Protein) Human Galectin-1 (LGALS1) Protein | |||
| abx670211-50ug | Abbexa | 50 ug | EUR 661.2 |
 Anti-human Galectin-3 antibody | |||
| STJ15100163 | St John's Laboratory | 250 µg | EUR 403.2 |
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation | |||
 ELISA kit for Human Galectin-1 | |||
| EK5323 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Galectin-1 in samples from serum, plasma, tissue homogenates and other biological fluids. | |||
 Galectin-1 Antibody | |||
| 3596-100 | Biovision | each | EUR 379.2 |
Galectin-1 Antibody | |||
| 3596-30T | Biovision | each | EUR 175.2 |
Galectin-1 Antibody | |||
| R34524-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Lectin, galactose binding, soluble 1; Lgals1 | |||
Galectin-1 Antibody | |||
| R34565-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
Description: Additional name(s) for this target protein: Lgals1 | |||
 anti- Galectin-3 antibody | |||
| FNab03316 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Galectin-3 | |||
anti- Galectin-3 antibody | |||
| FNab03317 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against Galectin-3 | |||
 anti- Galectin-7 antibody | |||
| FNab03318 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Galectin-7 | |||
 Human Galectin 8 Antibody | |||
| 33159-05111 | AssayPro | 150 ug | EUR 313.2 |
 Human Galectin 2 Antibody | |||
| 33165-05111 | AssayPro | 150 ug | EUR 313.2 |
 Human Galectin 13 Antibody | |||
| 33175-05111 | AssayPro | 150 ug | EUR 313.2 |
 Human Galectin 10 Antibody | |||
| 32652-05111 | AssayPro | 150 ug | EUR 313.2 |
 Recombinant Human Galectin-1 Protein | |||
| PROTP09382-1 | BosterBio | 50ug | EUR 380.4 |
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues. | |||
Recombinant Human Galectin-1 Protein | |||
| RP00007 | Abclonal | 20 μg | EUR 208.8 |
 CLIA Kit) Human Galectin 1 (GAL1) CLIA Kit | |||
| 20-abx190336 | Abbexa |
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Human Galectin 1 (GAL1) CLIA Kit | |||
| abx196676-96tests | Abbexa | 96 tests | EUR 990 |
CLIA Kit) Human Galectin 1 (GAL1)CLIA Kit | |||
| SCA321Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6777.36 |
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. | |||
Human Galectin 1 (GAL1)CLIA Kit | |||
| SCA321Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 663.31 |
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. | |||
Human Galectin 1 (GAL1)CLIA Kit | |||
| SCA321Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 896.16 |
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. | |||
Human Galectin 1 (GAL1)CLIA Kit | |||
| SCA321Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3672.72 |
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1) in serum, plasma and other biological fluids. | |||
Human Galectin 1 (GAL1) CLIA Kit | |||
| 4-SCA321Hu | Cloud-Clone |
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Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Galectin 1 (GAL1)Serum, plasma and other biological fluids | |||
 ELISA kit) Human Galectin-1(LGALS1) ELISA kit | |||
| CSB-EL012882HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1 (LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. | |||
Human Galectin-1(LGALS1) ELISA kit | |||
| 1-CSB-EL012882HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1(LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. | |||
Human Galectin-1(LGALS1) ELISA kit | |||
| E01G0448-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
Human Galectin-1(LGALS1) ELISA kit | |||
| E01G0448-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
Human Galectin-1(LGALS1) ELISA kit | |||
| E01G0448-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human Galectin-1(LGALS1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. | |||
 Antibody (Biotin Conjugate)) Human Galectin-1 (Gal-1) Antibody (Biotin Conjugate) | |||
| 30005-05121 | AssayPro | 150 ug | EUR 442.8 |
 ELISA kit) Human Galectin 1 (GAL1) ELISA kit | |||
| 201-12-3227 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. | |||
 ELISA Kit) Human Galectin 1 (GAL1) ELISA Kit | |||
| DLR-GAL1-Hu-48T | DL Develop | 48T | EUR 574.8 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| DLR-GAL1-Hu-96T | DL Develop | 96T | EUR 745.2 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. | |||
) Human Galectin 1 ELISA Kit (GAL1) | |||
| RK01436 | Abclonal | 96 Tests | EUR 625.2 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| RDR-GAL1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| RDR-GAL1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
ELISA Kit) Human Galectin 1(GAL1)ELISA Kit | |||
| QY-E04196 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| RD-GAL1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 573.6 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| RD-GAL1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 794.4 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| SEA321Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4091.29 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| SEA321Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 442.1 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| SEA321Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 580.15 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| SEA321Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2250.68 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Galectin 1 (GAL1) in serum, plasma, tissue homogenates and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| 4-SEA321Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Galectin 1 (GAL1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| RD-GAL1-Hu-48T | Reddot Biotech | 48T | EUR 411.8 |
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| RD-GAL1-Hu-96T | Reddot Biotech | 96T | EUR 588.3 |
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA kit | |||
| YLA3564HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Galectin 1 (GAL1) ELISA kit | |||
| YLA3564HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
Human Galectin 1 (GAL1) ELISA Kit | |||
| RDR-GAL1-Hu-48T | Reddot Biotech | 48T | EUR 432.39 |
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | |||
Human Galectin 1 (GAL1) ELISA Kit | |||
| RDR-GAL1-Hu-96T | Reddot Biotech | 96T | EUR 617.72 |
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | |||
 Polyclonal Antibody (Human)) Galectin 1 (GAL1) Polyclonal Antibody (Human) | |||
| 4-PAA321Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Galectin 1 (GAL1) | |||
 Galectin 1 antibody | |||
| 70R-GR002 | Fitzgerald | 100 ug | EUR 571.2 |
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody | |||
Galectin 1 antibody | |||
| 70R-11939 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal Galectin 1 antibody | |||
Galectin 1 antibody | |||
| 70R-13963 | Fitzgerald | 100 ug | EUR 386.4 |
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody | |||
Galectin 1 antibody | |||
| 70R-49997 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal Galectin 1 antibody | |||
 Galectin 1 Antibody | |||
| 49673-100ul | SAB | 100ul | EUR 399.6 |
Galectin 1 Antibody | |||
| 49673-50ul | SAB | 50ul | EUR 286.8 |
Galectin 1 Antibody | |||
| DF8089 | Affbiotech | 200ul | EUR 420 |
Galectin 1 Antibody | |||
| DF2383 | Affbiotech | 200ul | EUR 420 |
Galectin 1 Antibody | |||
| R31924 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creatingimmune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process. | |||
Galectin 1 Antibody | |||
| R32841 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creating immune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process. | |||
Galectin 1 Antibody | |||
| R32842 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin-1 expression in Hodgkin Lymphoma has also been shown to mediate immunosuppression of CD8+ T-cells. It is thought to play a role in creating immune tolerance in pregnancy. It has been found that Galectin-1-mediated production of IL6 may assist in augmenting the innate immune response against NiV. Galectin-1 may also be a significant factor that augments the efficiency of the HIV-1 infection process. | |||
 Human Galectin-1 PicoKine ELISA Kit | |||
| EK0762 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of human Galectin-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). | |||
 Human LGALS1/ Galectin-1 ELISA Kit | |||
| E1450Hu | Sunlong | 1 Kit | EUR 644.4 |
 ELISA Kit) Human LGALS1(Galectin-1) ELISA Kit | |||
| EH0626 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.469 ng/ml | |||
 anti- Galectin 2 antibody | |||
| FNab03310 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Galectin 2 | |||
 anti- Galectin 4 antibody | |||
| FNab03311 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Galectin 4 | |||
 anti- Galectin 8 antibody | |||
| FNab03312 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Galectin 8 | |||
 anti- Galectin 9 antibody | |||
| FNab03313 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Galectin 9 | |||
) Human Galectin-7 (LGALS7) | |||
| 1-CSB-RP097274h | Cusabio |
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Description: Recombinant Human Galectin-7(LGALS7) expressed in E.coli | |||
) Human Galectin-9 (LGALS9) | |||
| 1-CSB-YP012895HU | Cusabio |
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Description: Recombinant Human Galectin-9(LGALS9) expressed in Yeast | |||
) Human Galectin-2 (LGALS2) | |||
| 1-CSB-EP012886HU | Cusabio |
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Description: Recombinant Human Galectin-2(LGALS2) expressed in E.coli | |||
Human Galectin-9 (LGALS9) | |||
| 1-CSB-EP012895HU | Cusabio |
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Description: Recombinant Human Galectin-9(LGALS9) expressed in E.coli | |||
