
NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells
Aberrant NOTCH3 signaling and overexpression is oncogenic, related with most cancers stem cells and drug resistance, but therapeutic concentrating on stays elusive. Right here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor via a protease cleavable linker to 2 antibodies with differential skills to inhibit signaling. The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization via each caveolin and clathrin-mediated pathways.
The non-inhibitory antibody additionally effectively endocytoses through clathrin with out inducing receptor clustering however with slower lysosomal co-localization kinetics. As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. Therapy of xenografts with NOTCH3-ADCs results in sustained tumor regressions, outperforms standard-of-care chemotherapy, and permits concentrating on of tumors that overexpress NOTCH3 impartial of signaling inhibition.
Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses
Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. Nonetheless, present molecular designs solely allow the usage of a small fraction of endogenous antibodies, limiting the therapeutic potential. Right here, we report Fc-binding antibody-recruiting molecules (Fc-ARMs) as the primary instance addressing this subject. Fc-ARMs are composed of an Fc-binding peptide and a concentrating on ligand, enabling the exploitation of endogenous antibodies via fixed affinity to the Fc area of antibodies, whose sequence is conserved in distinction to the Fab area.
We present that Fc-ARM concentrating on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α+ most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro. Fc-ARMs efficiently interacted with antibodies in vivo and amassed in tumors. Moreover, Fc-ARMs recruited antibodies to suppress tumor progress in a mouse mannequin. Thus, Fc-ARMs have the potential to be a novel class of most cancers immunotherapeutic brokers.
Significance of hepatitis B floor antigen, IgM/IgG core antibody and hepatitis B virus DNA in blood donors
Introduction: Identification of hepatitis B virus carriers in blood donors is crucial with a view to keep away from transmission of the illness through blood transfusion.
Goal: To find out if blood donors with constructive outcomes for serological markers HBsAg and anti-HBc have been hepatitis B virus DNA carriers.
Strategies: 12,745 samples have been collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. All samples that examined constructive for one, two or all three markers have been analyzed with molecular methods to find out the presence of viral DNA.
Outcomes: 27.5 % of the samples that have been reactive for anti-HBc alone and 100 % of these with constructive outcomes for HbsAg and IgM/IgG anti-HBc have been recognized to include hepatitis B virus DNA (p = 0.001).
Conclusions: The choice of an infection markers, in addition to the detection strategies outline the outcomes. Performing two serological and one molecular check is necessary with a view to establish hepatitis B virus carriers and stop its transmission.
Introducción: La identificación de portadores del virus de la hepatitis B en donantes de sangre es imperativo para evitar la transmisión de la enfermedad a través de transfusiones sanguíneas.
Objetivo: Determinar si los donantes de sangre con resultados positivos en los marcadores serológicos HbsAg y anti-HBc eran portadores del ADN del virus de la hepatitis B.
Métodos: Se recolectaron 12 745 muestras de seis bancos de sangre ecuatorianos, las cuales fueron analizadas con pruebas serológicas para identificar marcadores infecciosos de HBsAg, anti-HBc, anti-HBs mediante ELISA automatizada. Todas las muestras positivas para uno, dos o los tres marcadores fueron analizadas con técnica molecular para determinar la presencia del ADN viral.
Resultados: Se identificó que 27.5 % de las muestras reactivas solo a anti-HBc y 100 % de las muestras con resultados positivos de HBsAg/anti-HBc-IgM/IgG presentaron ADN del virus de la hepatitis B (p = 0.001).
Conclusiones: La elección de los marcadores de infección y los métodos de detección definen los resultados. Es importante la realización de dos pruebas serológicas y una molecular para identificar a los portadores del virus de la hepatitis B y evitar su transmisión.

Two human antibodies to a meningococcal serogroup B vaccine antigen improve binding of complement Issue H by stabilizing the Issue H binding web site
Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds a number of complement regulators, together with human Issue H (FH). FH binding protein (FHbp) is a element of two licensed meningococcal vaccines and in mice FHbp elicits antibodies that inhibit binding of FH to FHbp, which defeat the bacterial evasion mechanism. Nonetheless, people vaccinated with FHbp develop antibodies that improve binding of FH to the micro organism, which might restrict the effectiveness of the vaccines. Within the current research, we present that two vaccine-elicited antibody fragments (Fabs) remoted from completely different human topics improve binding of complement FH to meningococcal FHbp by ELISA.
The 2 Fabs have completely different results on the kinetics of FH binding to immobilized FHbp as measured by floor plasmon resonance. The 1.7- and a couple of.0-Å decision X-ray crystal buildings of the Fabs in complexes with FHbp illustrate that the 2 Fabs bind to comparable epitopes on the amino-terminal area of FHbp, adjoining to the FH binding web site.
Superposition fashions of ternary complexes of every Fab with FHbp and FH present that there’s probably minimal contact between the Fabs and FH. Collectively, the buildings reveal that the Fabs improve binding of FH to FHbp by altering the conformations and mobilities of two loops adjoining to the FH binding web site of FHbp. As well as, the 1.5 Å-resolution construction of one of many remoted Fabs defines the structural rearrangements related to binding to FHbp. The FH-enhancing human Fabs, that are mirrored within the human polyclonal antibody responses, have necessary implications for tuning the effectiveness of FHbp-based vaccines.
![]() Integrin alpha-5 Antibody |
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abx234347-100ug | Abbexa | 100 ug | EUR 610.8 |
![]() Integrin alpha 5 Antibody |
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AF5200 | Affbiotech | 200ul | EUR 420 |
![]() Integrin alpha 5 Antibody |
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49269-100ul | SAB | 100ul | EUR 399.6 |
![]() Integrin alpha 5 Antibody |
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49269-50ul | SAB | 50ul | EUR 286.8 |
![]() Integrin alpha 5 Antibody |
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F41992-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq]. |
![]() Integrin alpha 5 Antibody |
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F49220-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq]. |
![]() Integrin alpha 5 Antibody |
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R31667 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
![]() Human Integrin Alpha 5 (ITGa5) Protein |
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20-abx067272 | Abbexa |
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![]() ELISA kit for Human Integrin alpha-5 |
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EK4913 | SAB | 96 tests | EUR 804 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Integrin alpha-5 in samples from serum, plasma, tissue homogenates and other biological fluids. |
![]() Human Integrin alpha-5(ITGA5) Elisa kit |
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CSB-E17350h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5 (ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
![]() Human Integrin alpha-5(ITGA5) Elisa kit |
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1-CSB-E17350h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5(ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
![]() Human Integrin alpha-5(ITGA5) Elisa kit |
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YLA4349HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
![]() Human Integrin alpha-5(ITGA5) Elisa kit |
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YLA4349HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
![]() Human Integrin Alpha 5 (ITGa5) CLIA Kit |
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20-abx492595 | Abbexa |
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![]() Human ITGA5(Integrin alpha-5) ELISA Kit |
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EH2445 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
![]() Human ITGA5/ Integrin alpha-5 ELISA Kit |
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E1342Hu | Sunlong | 1 Kit | EUR 726 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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20-abx151987 | Abbexa |
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![]() Human Integrin Alpha 5 (ITGA5) ELISA Kit |
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abx571172-96tests | Abbexa | 96 tests | EUR 886.8 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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DLR-ITGa5-Hu-48T | DL Develop | 48T | EUR 597.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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DLR-ITGa5-Hu-96T | DL Develop | 96T | EUR 776.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids. |
![]() Human Integrin alpha- 5, ITGA5 ELISA KIT |
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ELI-07691h | Lifescience Market | 96 Tests | EUR 988.8 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RDR-ITGa5-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 626.4 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RDR-ITGa5-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
![]() Human Integrin Alpha 5(ITGa5) ELISA Kit |
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QY-E05294 | Qayee Biotechnology | 96T | EUR 472.8 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RD-ITGa5-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RD-ITGa5-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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SEB287Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5402.92 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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SEB287Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 550.13 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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SEB287Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 734.46 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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SEB287Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2945.08 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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4-SEB287Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha 5 (ITGa5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RD-ITGa5-Hu-48T | Reddot Biotech | 48T | EUR 432.3 |
Description: tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RD-ITGa5-Hu-96T | Reddot Biotech | 96T | EUR 617.5 |
Description: tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RDR-ITGa5-Hu-48T | Reddot Biotech | 48T | EUR 453.92 |
Description: tissue homogenates, cell lysates and other biological fluids. |
![]() Human Integrin Alpha 5 (ITGa5) ELISA Kit |
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RDR-ITGa5-Hu-96T | Reddot Biotech | 96T | EUR 648.38 |
Description: tissue homogenates, cell lysates and other biological fluids. |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human) |
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4-PAB287Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5) |
![]() Integrin Alpha 5 (ITGa5) Antibody |
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20-abx101634 | Abbexa |
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![]() Integrin Alpha 5 (ITGa5) Antibody |
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20-abx101635 | Abbexa |
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![]() Integrin Alpha 5 (ITGa5) Antibody |
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20-abx172956 | Abbexa |
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![]() Integrin Alpha 5 (ITGa5) Antibody |
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20-abx179024 | Abbexa |
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![]() Integrin alpha 5 (CD49e) Antibody |
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abx216264-100ug | Abbexa | 100 ug | EUR 526.8 |
![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx325454 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx327245 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx113185 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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abx026655-400ul | Abbexa | 400 ul | EUR 627.6 |
![]() Integrin Alpha 5 (ITGA5) Antibody |
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abx026655-80l | Abbexa | 80 µl | EUR 343.2 |
![]() Integrin Alpha 5 (ITGa5) Antibody |
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20-abx129339 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx323564 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx338742 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx006811 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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20-abx000873 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody |
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abx011678-100ul | Abbexa | 100 ul | EUR 493.2 |
![]() Integrin alpha 5 Antibody (ITGA5) |
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F41992-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq]. |
![]() Integrin alpha 5 Antibody (ITGA5) |
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F49220-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq]. |
![]() Integrin alpha 5 Antibody / ITGA5 |
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RQ4096 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
![]() Integrin alpha 5 Antibody / ITGA5 |
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RQ5245 | NSJ Bioreagents | 100ul | EUR 356.15 |
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq] |
![]() Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody |
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CABT-49626MH | Creative Diagnostics | 0.1 mg | EUR 1650 |
![]() Integrin alpha 5 Conjugated Antibody |
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C49269 | SAB | 100ul | EUR 476.4 |
![]() Integrin alpha 5 Rabbit mAb |
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A19069-100ul | Abclonal | 100 ul | EUR 492 |
![]() Integrin alpha 5 Rabbit mAb |
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A19069-200ul | Abclonal | 200 ul | EUR 685.2 |
![]() Integrin alpha 5 Rabbit mAb |
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A19069-20ul | Abclonal | 20 ul | EUR 265.2 |
![]() Integrin alpha 5 Rabbit mAb |
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A19069-50ul | Abclonal | 50 ul | EUR 344.4 |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), PE |
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4-PAB287Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with PE. |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), APC |
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4-PAB287Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with APC. |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), Cy3 |
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4-PAB287Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with Cy3. |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), HRP |
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4-PAB287Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with HRP. |
![]() Recombinant Antibody to Integrin Alpha 5 (ITGa5) (Human) |
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4-RAB287Hu21 | Cloud-Clone |
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Description: A Recombinant antibody against Human Integrin Alpha 5 (ITGa5) |
![]() ELISA kit for Human ITGa5 (Integrin Alpha 5) |
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ELK3746 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of Integrin Alpha 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), FITC |
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4-PAB287Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with FITC. |
![]() Integrin Alpha 5 (ITGA5) Antibody (HRP) |
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20-abx336126 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody (FITC) |
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20-abx336127 | Abbexa |
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![]() Integrin Alpha 5 (ITGA5) Antibody (FITC) |
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abx413989-01mg | Abbexa | 0.1 mg | EUR 610.8 |
![]() anti- Integrin alpha-1 antibody |
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FNab04343 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Integrin alpha-1 |
![]() anti- Integrin alpha-3 antibody |
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FNab04344 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Integrin alpha-3 |
![]() anti- Integrin alpha-3 antibody |
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FNab04345 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against Integrin alpha-3 |
![]() anti- Integrin alpha-4 antibody |
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FNab04346 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Integrin alpha-4 |
![]() anti- Integrin alpha-9 antibody |
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FNab04348 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Integrin alpha-9 |
![]() Integrin Alpha 5 (ITGA5) Antibody (Biotin) |
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20-abx336128 | Abbexa |
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![]() Integrin alpha-5 Recombinant Protein |
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91-433 | ProSci | 0.05 mg | EUR 651.3 |
Description: Integrin alpha-5 belongs to the Integrin alpha chain family and contains 7 FG-GAP repeats. Integrin alpha-5 joins with Integrin- beta 1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin alpha-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling. |
![]() Recombinant Integrin Alpha 5 (ITGa5) |
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4-RPB287Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Integrin Alpha 5 expressed in: E.coli |
![]() Recombinant Integrin Alpha 5 (ITGa5) |
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4-RPB287Hu01 | Cloud-Clone |
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Description: Recombinant Human Integrin Alpha 5 expressed in: E.coli |
![]() Recombinant Integrin Alpha 5 (ITGa5) |
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4-RPB287Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Integrin Alpha 5 expressed in: E.coli |
![]() Human Integrin alpha-2 (ITGA2) |
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1-CSB-YP011864HU | Cusabio |
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Description: Recombinant Human Integrin alpha-2(ITGA2),partial expressed in Yeast |