Progress in Gynecologic Cancers with Antibody Drug Conjugates
Objective of evaluate: This text supplies a complete evaluate of antibody-drug conjugates (ADCs) beneath investigation in gynecologic cancers. The construction and performance of ADCs are reviewed with a deal with medical profit in addition to toxicity profiles.
Latest findings: A number of ADCs with varied goal antigens have been investigated in ovarian, cervical, and endometrial most cancers. ADCs have constantly demonstrated favorable security/tolerability profiles each as monotherapy and together remedy. In ovarian most cancers, response charges have ranged from 9 to 46% for monotherapy with response charges as excessive as 83% together remedy. In sufferers with cervical most cancers with progressive illness regardless of doublet remedy and bevacizumab, response charges as excessive as 24% have been noticed. ADCs characterize a quickly evolving area of focused remedy which have demonstrated notable medical profit each as monotherapy but additionally together remedy with an general favorable toxicity profile. With continued refinement of the goal biomarkers utilized, improved medical profit is more likely to be noticed.
Low seroprevalence of SARS-CoV-2 antibodies in a liver transplant cohort
Stable organ transplant recipients would possibly be at larger threat for acquisition and mortality on account of SARS-CoV-2. There isn’t a knowledge concerning SARS-CoV-2 seroprevalence amongst liver transplant (LT) recipients, and whether or not it’s totally different from that of the final inhabitants or different immunosuppressed teams. We evaluated the prevalence of IgG SARS-CoV-2 antibodies amongst LT recipients to estimate the frequency of asymptomatic SARS-CoV-2 an infection utilizing serological assays in our outpatient clinic. We performed a cross-sectional evaluation from Could 10th to October 26th 2020 of all grownup (>18 years) LT recipients that underwent a routine laboratory check for the outpatient clinic follow-up on the Hospital Universitari Vall d’Hebron (Barcelona) during which we included serological testing for SARS-CoV-2. 9 out of 294 LT recipients (3.1%) examined optimistic for anti-SARS-CoV-2 IgG antibodies.
5 of them (55.5%) had suffered clinically symptomatic SARS-CoV2 an infection confirmed by RT-PCR, 4 (44.4%) had offered suitable signs however with out microbiological affirmation and just one affected person (1/9, 11.1%) examined optimistic with none earlier symptom. SARS-CoV-2 seroprevalence amongst LT recipients in an space extremely affected by the pandemic is decrease than within the basic inhabitants in the identical space. These outcomes render the potential of asymptomatic an infection in LT recipients not possible.
Novel antibody cocktail concentrating on Guess v 1 quickly and sustainably treats birch allergy signs in a Part 1 examine
Background: The efficacy of an allergen-specific IgG cocktail to deal with cat allergy means that allergen-specific IgG could also be a significant protecting mechanism elicited by allergen immunotherapy.
Goal: Extending these findings, we examined a Guess v 1-specific antibody cocktail in birch-allergic topics.
Strategies: Part 1, randomized, double-blind, examine: Half-A, ascending doses of Guess v 1-specific antibody cocktail “REGN5713/14/15” (150-900 mg) in 32 wholesome adults; Half-B, single subcutaneous 900 mg dose or placebo in 64 birch-allergic topics. Complete nasal symptom rating (TNSS) response to titrated birch extract nasal allergen problem (NAC) and pores and skin prick check (SPT) with birch and alder allergen have been assessed at screening and days 8, 29, 57 and 113 (SPT solely); basophil activation checks (n=26) have been performed.
Outcomes: Single dose REGN5713/14/15 considerably diminished TNSS following birch NAC relative to baseline. Variations in TNSS AUC(0-1 hr) versus placebo (day 8: -1.17, P = .001; day 29: -1.18, P = .001; day 57: -0.85, P = .024) and titration SPT with birch distinction in AUC of imply wheal diameters versus placebo (all P < .001) have been sustained for ≥2 months; comparable outcomes noticed with alder SPT. REGN5713/14/15 was well-tolerated. Basophil responsiveness to birch-related allergens was considerably decreased in REGN5713/14/15-treated topics versus placebo on days 8, 57, and 113 (all P < .01).
Conclusion: Single dose REGN5713/14/15 was effectively tolerated and offered a speedy (1 week) and sturdy (2 months) discount in allergic signs after birch allergen NAC, probably providing a brand new paradigm for the remedy of birch allergy signs.
Transfusion-induced platelet antibodies and regulatory T cells in multiply transfused sufferers
Background: Platelet transfusion refractoriness (PTR) stays a tough drawback in sufferers requiring long-term platelet supportive care. Nonetheless, there are little knowledge on the frequency of platelet antibodies in multiply transfused Chinese language sufferers. Furthermore, the connection between peripheral regulatory T cells (Tregs) and PTR stays unclear.
Strategies: We retrospectively studied the frequency of alloimmunization towards platelet antigens in sufferers receiving a number of transfusions between 2013 and 2017. Monoclonal antibody solid-phase platelet antibody check (MASPAT) kits have been used to display screen for platelet antibodies earlier than every platelet transfusion. Peripheral Tregs and CD4+ CD25+ CD127– T cells have been detected by circulate cytometry, whereas reworking progress factor-beta (TGF-β) and interleukin (IL)-17 cytokines have been detected by enzyme-linked immunosorbent assay.
Outcomes: A complete of 399 sufferers who met the inclusion standards have been enrolled for the evaluation of platelet antibodies and refractoriness. Amongst these sufferers, 10 (2.5%) have been optimistic for platelet antibodies earlier than transfusion and 47 (11.8%) grew to become antibody-positive throughout the examine interval. The variety of alloimmunized sufferers was considerably greater in sufferers with hematological illness as in contrast with different illness teams (p < 0.05). Refractoriness and alloimmunization occurred in 77 (19.3%) and 22 (28.6%) sufferers, respectively. There have been no vital variations in CD4+ , CD8+ , and CD4+ CD25+ CD127– T cell numbers and plasma ranges of TGF-β1 and IL-17 between sufferers with PTR and the management group.
Conclusions: Refractoriness was frequent in sufferers present process a number of platelet transfusions (19.3%), with alloimmunization noticed in 28.6% of sufferers. Nonetheless, Tregs in peripheral blood might not play a key position in PTR.
Younger infants exhibit strong purposeful antibody responses and restrained IFN-γ manufacturing to SARS-CoV-2
Extreme COVID-19 seems uncommon in kids. That is surprising, particularly in younger infants, who’re susceptible to extreme illness attributable to different respiratory viruses. We consider convalescent immune responses in 4 infants beneath 3 months previous with confirmed COVID-19 who offered with delicate febrile sickness, alongside their dad and mom, and grownup controls recovered from confirmed COVID-19.
Though not statistically vital, in comparison with seropositive adults, infants have excessive serum ranges of IgG and IgA to SARS-CoV-2 spike protein with corresponding purposeful skill to dam SARS-CoV-2 mobile entry. Infants additionally exhibit strong saliva anti-spike IgG and IgA responses. Spike-specific IFN-γ manufacturing by toddler peripheral blood mononuclear cells seems restrained, however the frequency of spike-specific IFN-γ and/or TNF-ɑ producing T cells is comparable between infants and adults. On principal part evaluation, toddler immune responses seem distinct from their dad and mom. Sturdy purposeful antibody responses alongside restrained IFN-γ manufacturing might assist defend infants from extreme COVID-19.
Salivary IgA antibody to malondialdehyde-acetaldehyde associates with delicate periodontal pocket depth
Goal: Oxidized epitopes reminiscent of malondialdehyde-acetaldehyde (MAA) play an important position within the development of atherosclerosis by way of activation of the humoral immune response. The precise mechanism of the affiliation between atherosclerosis and periodontal illnesses shouldn’t be totally understood. The purpose of the present examine is to judge the affiliation of oral humoral immune response to oxidized epitopes with parameters of periodontal illness.
Supplies and strategies: The Parogene cohort encompass sufferers who’ve undergone coronary angiography on account of cardiac signs. On this examine, 423 sufferers have been randomly chosen for an in depth oral examination. Salivary Immunoglobulin A to oxidized epitopes and bacterial antigens was decided by chemiluminescence immunoassay.
Outcomes: In a binary logistic regression mannequin adjusted with periodontal illness confounders, periodontal pocket depth (PPD) 4-5 mm related to salivary IgA antibodies to MAA-LDL (p = 0.034), warmth shock protein 60 of Aggregatibacter actinomycetemcomitans (p = 0.045), Porphyromonas gingivalis (p = 0.045), A. actinomycetemcomitans (p = 0.005), P. intermedia (p = 0.020), and complete IgA (p = 0.003).
Conclusions: The present examine reveals the affiliation of salivary IgA to MAA-LDL with PPD 4-5 mm in a cohort of sufferers with continual coronary artery illness. Humoral immune cross-reactivation to oxidized epitopes such MAA-LDL may partly clarify the hyperlink of periodontitis with systemic illnesses.
 Rabbit Anti-Mouse LIF | |||
| 103-PA05 | Angio Proteomie | 100ug | EUR 240 |
 Mouse LIF Protein | |||
| E40MOP1672 | EnoGene | 20ug | EUR 495 |
Mouse LIF Protein | |||
| E40MOP2026 | EnoGene | 20ug | EUR 495 |
Mouse LIF Protein | |||
| E40MOP2028 | EnoGene | 20ug | EUR 495 |
 Recombinant Mouse LIF | |||
| Z200195 | ABM | 10 µg | EUR 85 |
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. | |||
Recombinant Mouse LIF | |||
| Z200197 | ABM | 100 µg | EUR 385 |
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. | |||
Recombinant Mouse LIF | |||
| Z200199 | ABM | 1.0 mg | EUR 1200 |
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation (2). It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1 (2). The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. | |||
Recombinant Mouse LIF | |||
| Z200485 | ABM | 100 µg | EUR 1500 |
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation (2). It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1 (2). The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130. | |||
 anti- LIF antibody | |||
| FNab09804 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against LIF | |||
anti- LIF antibody | |||
| LSMab09804 | Lifescience Market | 100 ug | EUR 463.2 |
 Mouse LIF ELISA Kit | |||
| E28L0650 | EnoGene | 96T | EUR 666.67 |
Mouse LIF ELISA Kit | |||
| EK5250 | SAB | 96 tests | EUR 599 |
Mouse LIF ELISA Kit | |||
| EML0014 | Abclonal | 96Tests | EUR 625.2 |
 Rat Monoclonal anti-mouse LIF | |||
| mAP-0122 | Angio Proteomie | 100ug | EUR 250 |
 Sheep Polyclonal anti-mouse LIF | |||
| mAP-5260 | Angio Proteomie | 50ug | EUR 400 |
 Mouse LIF shRNA Plasmid | |||
| 20-abx971321 | Abbexa |
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 Mouse LIF Recombinant Protein | |||
| M30-007 | ReliaTech | 10 µg | EUR 99.75 |
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF. Recombinant mouse LIF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 180 amino acids and having a molecular mass of 19.86 kDa. | |||
Mouse LIF Recombinant Protein | |||
| M30-008 | ReliaTech | 50 µg | EUR 246.75 |
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF. Recombinant mouse LIF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 180 amino acids and having a molecular mass of 19.86 kDa. | |||
 Recombinant Mouse LIF Protein | |||
| R01400-1 | BosterBio | 100ug/vial | EUR 352.8 |
Recombinant Mouse LIF Protein | |||
| PKSM041100-100ug | Elabscience Biotech | 100ug | EUR 739 |
Description: Mouse | |||
Recombinant Mouse LIF Protein | |||
| PKSM041100-20ug | Elabscience Biotech | 20ug | EUR 249 |
Description: Mouse | |||
 Mouse LIF PicoKine ELISA Kit | |||
| EK0580 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA). | |||
 Anti-Human LIF Antibody | |||
| 101-M553 | ReliaTech | 100 µg | EUR 399 |
Description: Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. | |||
Anti-Human LIF Antibody | |||
| 102-PA05S | ReliaTech | 100 µg | EUR 126 |
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF. | |||
 LIF mouse monoclonal antibody, clone 4F7.2 | |||
| MO16101-100 | Origene Technologies GmbH | 100 µg | Ask for price |
 LIF mouse monoclonal antibody, clone 2H2.2 | |||
| MO16102-100 | Origene Technologies GmbH | 100 µg | Ask for price |
 (pORF)) Lif ORF Vector (Mouse) (pORF) | |||
| ORF049145 | ABM | 1.0 ug DNA | EUR 607.2 |
Lif ORF Vector (Mouse) (pORF) | |||
| ORF049146 | ABM | 1.0 ug DNA | EUR 607.2 |
 Rabbit Anti-Human LIF | |||
| 102-PA05 | Angio Proteomie | 100ug | EUR 240 |
 (OKBB00760)) LIF ELISA Kit (Mouse) (OKBB00760) | |||
| OKBB00760 | Aviva Systems Biology | 96 Wells | EUR 606 |
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml | |||
 LIF, Mouse Recombinant , 1MIU/ml | |||
| L4500-001 | GenDepot | 1ml | EUR 406.8 |
LIF, Mouse Recombinant , 1MIU/ml | |||
| L4500-005 | GenDepot | 5x1ml | EUR 1431.6 |
 (OKEH04045)) LIF ELISA Kit (Mouse) (OKEH04045) | |||
| OKEH04045 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL | |||
 LIF, Mouse Recombinant , 10MIU/ml | |||
| L4501-001 | GenDepot | 1ml | EUR 1744.8 |
 Nori® Mouse LIF ELISA Kit | |||
| GR117058 | Genorise Scientific | 96-well | EUR 461 |
 Mouse LIF Recombinant Protein Lyophilized | |||
| IMSLIFRLY5UG | Innovative research | each | EUR 317 |
Description: Mouse LIF Recombinant Protein Lyophilized | |||
 Human CellExp? LIF, mouse recombinant | |||
| 7268-10 | Biovision | each | EUR 444 |
 Mouse LIF protein, C-His tag | |||
| PRP1126-100ug | Abbkine | 100 μg | EUR 379 |
Description: Mouse LIF protein, C-His tag, expressed in E. coli | |||
Mouse LIF protein, C-His tag | |||
| PRP1126-1mg | Abbkine | 1 mg | EUR 2509 |
Description: Mouse LIF protein, C-His tag, expressed in E. coli | |||
Mouse LIF protein, C-His tag | |||
| PRP1126-20ug | Abbkine | 20 μg | EUR 149 |
Description: Mouse LIF protein, C-His tag, expressed in E. coli | |||
Mouse LIF protein, C-His tag | |||
| PRP1126-5ug | Abbkine | 5 μg | EUR 59 |
Description: Mouse LIF protein, C-His tag, expressed in E. coli | |||
, mouse) Leukemia Inhibitory Factor (LIF), mouse | |||
| PR16102 | Neuromics | 5 ug | EUR 522 |
Leukemia Inhibitory Factor (LIF), mouse | |||
| PR16102-B | Neuromics | each | EUR 436.5 |
 - Mouse leukemia inhibitory factor (Lif), transcript variant 1, (10ug)) Lif (untagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 1, (10ug) | |||
| MC208887 | Origene Technologies GmbH | 10 µg | Ask for price |
 - Mouse leukemia inhibitory factor (Lif), transcript variant 2, (10ug)) Lif (untagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 2, (10ug) | |||
| MC208888 | Origene Technologies GmbH | 10 µg | Ask for price |
 Recombinant Mouse Lif Protein, No Tag | |||
| E40MOP2217 | EnoGene | 20ug | EUR 495 |
 - Mouse leukemia inhibitory factor (Lif) transcript variant 1, (10ug)) Lif (GFP-tagged) - Mouse leukemia inhibitory factor (Lif) transcript variant 1, (10ug) | |||
| MG223120 | Origene Technologies GmbH | 10 µg | Ask for price |
 - Mouse leukemia inhibitory factor (Lif) transcript variant 2, (10ug)) Lif (GFP-tagged) - Mouse leukemia inhibitory factor (Lif) transcript variant 2, (10ug) | |||
| MG223901 | Origene Technologies GmbH | 10 µg | Ask for price |
 - Mouse leukemia inhibitory factor (Lif), transcript variant 1) Lif (Myc-DDK-tagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 1 | |||
| MR223120 | Origene Technologies GmbH | 10 µg | Ask for price |
 - Mouse leukemia inhibitory factor (Lif), transcript variant 2) Lif (Myc-DDK-tagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 2 | |||
| MR223901 | Origene Technologies GmbH | 10 µg | Ask for price |
) OKBB00760-96W - LIF ELISA Kit (Mouse) | |||
| OKBB00760-96W | Aviva Systems Biology | 96wells | EUR 538 |
) OKEH04045-96W - LIF ELISA Kit (Mouse) | |||
| OKEH04045-96W | Aviva Systems Biology | 96Wells | EUR 425 |
) Lif sgRNA CRISPR Lentivector set (Mouse) | |||
| K3872501 | ABM | 3 x 1.0 ug | EUR 406.8 |
 Sheep Polyclonal anti-human LIF | |||
| hAP-5294 | Angio Proteomie | 50ug | EUR 400 |
 Polyclonal Antibody (Mouse)) Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse) | |||
| 4-PAA085Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF) | |||
) LIF, Leukemia inhibitory factor, murine (mouse) | |||
| RC234-18 | Bio Basic | 5ug | EUR 125.26 |
 Protein) Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| 20-abx067761 | Abbexa |
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Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-1mg | Abbexa | 1 mg | EUR 3801.6 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-3x10g | Abbexa | 3x10 µg | EUR 393.6 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-3x2g | Abbexa | 3x2 µg | EUR 276 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx067761-10g | Abbexa | 10 µg | EUR 212.5 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx067761-50g | Abbexa | 50 µg | EUR 387.5 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx067761-100g | Abbexa | 100 µg | EUR 550 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-10mg | Abbexa | 10 mg | EUR 325 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-25mg | Abbexa | 25 mg | EUR 3287.5 |
Mouse Leukemia Inhibitory Factor (LIF) Protein | |||
| abx262959-5mg | Abbexa | 5 mg | EUR 225 |
 Mouse LIF Flow Cytometry Assay - Group 3 | |||
| MX85121 | Antigenix America | 96 Tests | EUR 270 |
) Mouse LIF Protein, His Tag (MALS verified) | |||
| LIF-M5227 | ACROBIOSYSTEMS | 1mg | EUR 321 |
Description: Mouse LIF, His Tag (LIF-M5227) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Phe 203 (Accession # P09056-1). | |||
) Mouse LIF Protein, Tag Free (MALS verified) | |||
| LIF-M5219 | ACROBIOSYSTEMS | 20ug | EUR 2856.9 |
Description: Mouse LIF Protein, Tag Free (LIF-M5219) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Phe 203 (Accession # P09056-1). | |||
 LIF Antibody | |||
| 6245-002mg | ProSci | 0.02 mg | EUR 206.18 |
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation. | |||
LIF Antibody | |||
| 6245-01mg | ProSci | 0.1 mg | EUR 523.7 |
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation. | |||
LIF Antibody | |||
| 25283-100ul | SAB | 100ul | EUR 468 |
LIF Antibody | |||
| 36950 | SAB | 100ul | EUR 319 |
LIF Antibody | |||
| 36950-100ul | SAB | 100ul | EUR 302.4 |
LIF Antibody | |||
| E036950 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. | |||
LIF Antibody | |||
| DF13730 | Affbiotech | 100ul | EUR 420 |
LIF Antibody | |||
| DF13730-100ul | Affinity Biosciences | 100ul | EUR 280 |
LIF Antibody | |||
| DF13730-200ul | Affinity Biosciences | 200ul | EUR 350 |
LIF Antibody | |||
| E91288 | EnoGene | 100μg | EUR 255 |
Description: Available in various conjugation types. | |||
LIF Antibody | |||
| E38PA4058 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. | |||
LIF Antibody | |||
| E315544 | EnoGene | 100ug/200ul | EUR 295 |
Description: Available in various conjugation types. | |||
 LIF antibody | |||
| 70R-12299 | Fitzgerald | 100 ug | EUR 343 |
Description: Rabbit polyclonal LIF antibody | |||
LIF antibody | |||
| 70R-14100 | Fitzgerald | 100 ug | EUR 519 |
Description: Affinity purified Rabbit polyclonal LIF antibody | |||
LIF Antibody | |||
| 5216-100 | Biovision | each | EUR 379.2 |
LIF Antibody | |||
| 5216-30T | Biovision | each | EUR 175.2 |
LIF antibody | |||
| 70R-6230 | Fitzgerald | 50 ug | EUR 467 |
Description: Rabbit polyclonal LIF antibody | |||
LIF antibody | |||
| 70R-51295 | Fitzgerald | 100 ul | EUR 242 |
Description: Purified Polyclonal LIF antibody | |||
LIF Antibody | |||
| 1-CSB-PA004761 | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 | |||
LIF Antibody | |||
| 1-CSB-PA012928ESR2HU | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA | |||
LIF Antibody | |||
| 1-CSB-PA198481 | Cusabio |
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Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100 | |||
LIF Antibody | |||
| GWB-MT498C | GenWay Biotech | 50ug | Ask for price |
